Recruitment and activation of RSK2 by HIV-1 Tat.
The transcriptional activity of the integrated HIV provirus is dependent on the chromatin organization of the viral promoter and the transactivator Tat.Tat recruits the cellular pTEFb complex and interacts with several chromatin-modifying enzymes, including the histone acetyltransferases p300 and MELATONIN PCAF.Here, we examined the interaction of